Operator Protection
Product Protection
Environmental Protection
Clean Air
Streamline® Compounding Isolator
Esco Pharma’s Streamline® Compounding Isolator (SCI) provides a sterile environment for sterile/aseptic preparations and is designed in compliance with USP <797> and <800> criteria. It is factory-configured to operate either in a positive or negative pressure mode or with a recirculating or total exhaust airflow scheme.
This compounding aseptic/sterile containment isolator (CACI) is designed in compliance with international cGMP standards and classified under Class 3 Leak Tight Containment as per ISO 10648-2.
Positive pressure is for sterile non-hazardous materials while negative pressure is for containment of sterile hazardous substances.
Key Benefits:
Complies with the international cGMP standards
Compliant to USP <797> and <800> guidelines
Class 3 pressure tested as per ISO 10648-2
ISO Class 5 air cleanliness as per ISO 14644-1
Fast purging time
ULPA filters
(as per IEST-RP-CC001.3 and HEPA (H14) filter as per EN 1822) with a typical efficiency of >99.999% at 0.1 to 0.3 microns, providing ISO Class 3 air cleanliness as per ISO 14644-1.
- Bag-In, Bag-Out (BIBO) HEPA filter configuration (optional) offers additional protection for the maintenance personnel and environment by ensuring that upon filter changing, the HEPA filters are already sealed in a bag prior to being fully removed from the isolator unit.
FDA-grade pressure-tight static seals
Sentinel™ Gold microprocessor controller
supervises all functions and monitors airflow and pressure in real-time.
Robust dual-wall construction.
Unique Esco Dynamic Chamber™ plenum surrounds filter seals with negative pressure.
Safe-change cuff rings
permit hypalon sleeve changes with zero risk of work zone or environment contamination.
- Critical for operations dealing with potent (volatile) liquid or powder materials
- Guarantees operator and environmental protection is achieved as it prevents cross-contamination risk
Airlock pass-through interchange
ensures main work zone remains sterile during insertion and removal of items.
- Has electromagnetic interlocking door mechanism with time-delayed ingress/egress control.
The unit is equipped with a Foot Switch to open the inner doors.
Interchangeable Pressure Configuration
the work zone and pass-through interchange can be configured to have positive or negative pressurization.
- Positive pressure is for sterile non-hazardous materials.
- Negative pressure is for containment of sterile hazardous substances.
Stainless steel drain pan
located below the work surface to contain spills.
Hinged window
may be opened for thorough access into the work zone.
Sliding Tray
The pass-through chamber has a sliding tray for easy ingress of materials into the work zone.
Unit can be factory-configured
to have either a recirculating or total exhaust/single pass airflow scheme:
- Recirculating airflow can be applied for compounding non-hazardous sterile drugs.
- As per recommendations of USP <797> for compounding aseptic isolator (CAI) units.
- Total exhaust/single pass airflow is recommended for facilities handling volatile hazardous drugs (HDs)/substances.
- Both USP <797> and <800> guidelines clearly define the use of a compounding aseptic containment isolator (CACI) for dealing with volatile HDs.
Recirculating Airflow
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Ambient air is pulled through the inlet pre-filter and main filter located on top of the isolator.
The downflow filter creates a laminar air flow providing ISO Class 5 air cleanliness (ISO 14644-1) to the main chamber and pass-through, with a down flow velocity of 0.40 m/s +/- 20%.
Air from the work zone and pass-through is quickly purged out by the exhaust fan to keep the area clean. The fan pulls approximately 90% of the purged air back to the plenum, passes through the HEPA downflow filter again, and is recirculated back to the work zone and pass-through.
Approximately 10% of the purged air is exhausted through the filter to prevent heat build-up inside the isolator.
Exhausted air is replenished by ambient air coming from the top inlet prefilter that has 80% efficiency.
Total Exhaust
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Ambient air is pulled through the inlet pre and main filter via the main fans at the top of the isolator. This creates positive pressure on the plenum which provides the downflow of air with a velocity of 0.40 m/s ± 20%.
The pre-filter extends the life of the filters by trapping larger particulates that can easily clog the main filters
This downflow supply then provides an ISO Class 5 environment and unidirectional airflow inside the isolator; thus, protecting the materials inside the main chamber and pass-through.
Air from the work zone and pass-through is then quickly purged by the fans to keep the area clean. The purge is completely exhausted through HEPA filters as well; ensuring that only clean air is exhausted back to the environment.
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Guide to Streamline® Compounding Isolator (SCI) models |
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SCI-3GC8-N1RL-1-SE |
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Isolator Unit |
Model |
No. of gloves - Nominal Width |
Glove port design |
Voltage Code |
Pressure |
Airflow Scheme |
Pass-Through zone |
Exhaust Type |
Code |
Sharps Provision |
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Streamline® Compounding Isolator |
SCI |
2G |
5 ft (1.6m) |
C |
Circular glove port (300 mm x 300 mm) |
8 |
220-240 V AC, 50/60Hz, 1Ø |
P0 |
Process zone: Pass -through zone: |
R |
Recirculating |
L |
1 Left |
Double HEPA Exhaust (BIBO Top and non-BIBO Bottom) |
1 |
Without |
0 |
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3G |
6 ft (1.95m) |
O |
Oval glove port (200 mm x 300 mm) |
9 |
110-120 V AC, 50/60Hz, 1Ø |
N1 |
Process zone: Pass -through zone: |
S |
Single Pass |
R |
1 Right |
Single Exhaust (Top, non-BIBO) |
2 |
With (inside work zone) 8 qts: 171.45 x 254 x 285.75mm |
SI |
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N2 |
Process zone: Pass -through zone: |
Single Exhaust (Top, BIBO) |
3 |
With (below work zone) 5 gal: 190.50 x 266.70 x 431.80mm |
SB |
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With (beside work zone) 5 gal: 190.50 x 266.70 x 431.80mm |
SE |
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GENERAL SPECIFICATIONS Streamline® Compounding Isolator |
SCI-2G |
SCI-3G |
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Main Chamber Nominal Size (Width) |
1.6 meters (5’) |
1.95 meters (6’) |
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External Dimension |
With sharps bin and exhaust collar |
1900 mm x 825 mm x 2535 mm (74.8" x 32.5" X 99.8) |
2205 mm x 825 mm x 2535 mm (86.8" x 32.5" X 99.8") |
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With sharps bin and without exhaust collar |
1900 mm x 825 mm x 2385 mm (74.8" x 32.5" X 93.9") |
2205 mm x 825 mm x 2385 mm (86.8" x 32.5" X 93.9") |
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Without sharps bin and with exhaust collar |
1645 mm x 825 mm x 2535 mm (64.8" x 32.5" X 99.8") |
1950 mm x 825 mm x 2535 mm (76.8" x 32.5" X 99.8") |
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Without sharps bin and without exhaust collar |
1645 mm x 825 mm x 2385 mm (64.8" x 32.5" X 93.9") |
1950 mm x 825 mm x 2385 mm (76.8" x 32.5" X 93.9") |
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Main Chamber Work Zone Internal Dimension (W x D x H) |
960 mm x 625 mm x 625mm (37.8" x 24.6" x 24.6") |
1265 mm x 625 mm x 625 mm (49.8" x 24.6" x 24.6") |
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Pass Through Internal Dimension(W x D x H) |
450 mm x 625 mm x 625 mm (17.7" x 24.6" x 24.6") |
450 mm x 625 mm x 625 mm (17.7" x 24.6" x 24.6") |
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Work Zone and Interchange Chamber Performance |
ISO Class 3 (Class 1, Federal Standard 209E) |
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Downflow and Exhaust Filter Type |
ULPA filter with integral metal guards and filter frame gaskets; fully compliant with EN 1822 (H14) and IEST-RP-CC001.3 requirements (each cabinet has individual downflow and exhaust filters) |
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Typical Filter Efficiency |
>99.999% for particle size between 0.1 to 0.3 micron |
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Airflow Volume |
Required Exhaust With Optional Hard Ducting |
Contact Esco for more information. |
190m3 / h (112 cfm) |
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Static Pressure For Optional Hard Ducting |
Contact Esco for more information. |
27 Pa / 0.10 in H2O |
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LED Light Intensity |
≥ 800 lux |
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Isolator Construction |
Main Body EG Steel |
1.5 mm (0.06”) 16 Gauge Electro-Galvanized Steel with White Oven-Baked Epoxy-Polyester Isocide Antimicrobial Powder Coated Finish |
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Main Body Stainless Steel |
1.5 mm (0.06”) 16 gauge stainless steel, type 304, with 4B finish |
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Work Tray |
1.5 mm (0.06”) 16 gauge stainless steel, type 316L, with 4B finish |
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Side Walls |
1.5 mm (0.06”) 16 gauge stainless steel, type 316L, with 4B finish |
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Electrical |
220-240V, AC, 50/60Hz, 1Ø |
SCI-2G- |
SCI-3G- |
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Cabinet Power Amp |
Contact Esco for more information. |
10 A |
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Cabinet Nominal Power |
Contact Esco for more information. |
362 W |
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Cabinet BTU |
Contact Esco for more information. |
1235 |
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110-120V,AC, 60 Hz, 1Ø |
SCI-2G- |
SCI-3G- |
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Cabinet Full Load Amp (FLA) |
6 A |
9.5 A |
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Optional Outlets FLA |
Contact Esco for more information. |
5 A |
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Cabinet Nominal Power |
Contact Esco for more information. |
362 W |
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Cabinet BTU |
Contact Esco for more information. |
1236 |
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Net Weight |
Contact Esco for more information. |
550 kg (1220 lbs) |
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Shipping Weight |
392.5 kg (865 lbs) |
620 kg (1370 lbs) |
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Shipping Dimensions, Maximum (W x D x H) |
1600 x 990 x 2210 mm (62.6” x 39.0” x 87.0”) |
1600 x 990 x 2250 mm (86.7” x 37.8” x 88.6”) |
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Shipping Volume, Maximum* |
3.48 m3 (122.9 ft3) |
4.75 m3 (167.7 ft3) |
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Optional Accessories |
UV Lamp |
5170543 |
5170543 |
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Carbon Filter |
5170225 |
5170225 |
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Adjustable Hydraulic Stand |
5131175 |
5131177 |
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CCTV Camera |
5180034 |
5180034 |
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Rear View |
5180033 |
5180033 |
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Standard Accessories
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Electromagnetic interlocking doors to prevent cross-contamination
Foot switch included to easily open the inner doors
Single-piece or multi-piece stainless steel 316L work top
Energy efficient LED lighting with higher durability and better quality
Electrical Outlets and Utility Fittings
Electrical outlet, ground fault, North America
Electrical outlet, Euro/Worldwide
Support Stands
Fixed height, available 711 mm (28") or 864 mm (34") - With levelling feet, ± 38.1 mm (1.5") (SAL) - With casters (SPC)
Telescoping height stand for levelling feet (STL), nominal range 660 mm to 960 mm (26"to 37.8")
Telescoping height stand for casters (STC), nominal range 660 mm to 880 mm (26" to 34.6") - Adjustable in 25.4 mm (1") increments
Infinitely adjustable hydraulic stand with casters elevates to accommodate a sitting or a standing user’s work surface height (SHM)
Support Stands
A 4-glove port (4G) design is possible by combining two units of 2-glove port (2G) isolators, interconnected by a vertical non-interlocking door; with two pass-through chambers.
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External material of construction:
Electrogalvanized steel with ISOCIDE™ powder coating
Stainless steel 304
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Dunk tank
One dunk tank below the work zone
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Exhaust types
Double HEPA exhaust filter (BIBO top and non-BIBO bottom)
Side Exhaust Connection (for TE units)
*Note: Additional carbon filter is available as an option for all exhaust filter configurations
IV bar, with hooks
UV lamp
Flexible / Thimble exhaust collar
Side Exhaust Connection (for TE units)
Hard ducting with Anti-blowback valve
Perforated shelf to increase work zone space
Cleaning accessories
Alarm package
Laboratory cart
Adjustable foot rest
Stainless steel turntable
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Butterfly valve:
Manual
Automatic
Add-Ons
Monitor System
Mounted on the rear of the isolator
Beside the front panel; equipped with a keyboard and mouse arm
Mobile BioVap™ biodecontamination system
Glove Leak Tester
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Automated pressure hold testing (APHT)
With on-board compressed air
with on-board pump
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CCTV integration
Back wall
Front of the visor with a stainless steel mount
Back-up battery for the electromagnetic interlocks (contact Esco for more information)
Side-syringe pass-through chamber
