Streamline® Closed Restricted Access Barrier System (SLC-RABS)

The Streamline® Closed Restricted Access Barrier System (SLC-RABS) provides a safe and clean environment for the preparation of sterile non-hazardous drugs in compliance to the United States Pharmacopeia General Chapter <797>.

Closed Restricted Access Barrier System (cRABS) provides a full unidirectional airflow scheme for an ISO Class 5 environment for aseptic processing. SLC-RABS is designed with a rigid wall enclosure and glove port access for process manipulation; this prevents the risk of cross-contamination. The interior of the enclosure is manually sanitised with process components introduced via pass-through chambers.

As such, cRABS provide superior sterility as compared to open front clean air devices (laminar flow clean benches and Class II biological safety cabinets). These systems are a safe and efficient solution for the production of low-volume pharmaceuticals as well as with practices concerning:

Operator aseptic technique training
Expiration settings
Product quality maintenance (once CSP leaves the pharmacy)

Furthermore, cRABS can reduce operating and renovation costs by taking up less space than a traditional cleanroom facility.

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Features

ULPA filters (as per IEST-RP-CC001.3 and HEPA (H14) filter as per EN 1822) with a typical efficiency of >99.995% at 0.1 to 0.3 microns, providing ISO Class 5 air cleanliness as per ISO 14644-1.
Sentinel™ Gold Microprocessor controller supervises all functions and monitors airflow and pressures in real-time.
For negatively pressured RABS, the work zone and pass-through chambers are under negative pressure to the room to maintain operator protection in the event of a breach in the system.
Positively pressured configurations are under positive pressure to the room to ensure product protection.
Robust dual-wall construction. The work zone is surrounded by negative pressure plenums at the sides and back. Unique Esco Dynamic Chamber™ plenum surrounds filter seals with negative pressure.
Ergonomically angled front and oval gloveports improve reach and comfort.
Safe-change cuff rings permit glove changing with zero risk of contaminating the work zone and/or pharmacy environment.
Easy to clean one-piece work zone liner.
Esco antimicrobial coating on all painted surfaces to minimize contamination.
Sharps disposal system and hydraulic height adjustable stand are available as options.

Principle

Recirculating Airflow

Ambient air is pulled through the inlet pre-filter and main filter located on top of the isolator.
The downflow filter creates a laminar air flow providing ISO Class 5 air cleanliness (ISO 14644-1) to the main chamber and pass-through, with a down flow velocity of 0.40 m/s +/- 20%.
Air from the work zone and pass-through is quickly purged out by the exhaust fan to keep the area clean. The fan pulls approximately 90% of the purged air back to the plenum, passes through the HEPA downflow filter again, and is recirculated back to the work zone and pass-through.
Approximately 10% of the purged air is exhausted through the filter to prevent heat build-up inside the isolator.
Exhausted air is replenished by ambient air coming from the top inlet prefilter that has 80% efficiency.

Models

Streamline^® Closed - Restricted Access Barrier System
SLC-RABS-4CN3-S
Unit	Model	Nominal Width		Glove Port Design		Pressure Scheme		Electrical Code		Sharps Provision
Streamline® Closed - Restricted Access Barrier System	SLC-RABS	4	4 ft (1.2 m)	C	Circular glove port (300 mm x 300 mm)	N	Negative	1	220-240 V, AC, 50 Hz, 1Ø	0	No
								2	110-120 V, AC, 50 Hz, 1Ø
		6	6 ft (1.8 m )	O	Oval glove port (200 mm x 300 mm)	P	Positive			S	Yes
								3	220-240 V, AC, 60 Hz, 1Ø

*Please note: Customer can also opt to choose a circular glove port, but if not indicated in the Purchase Order, the default is a standard oval glove port.

		SLC-RABS-4N-_-	SLC-RABS-4P-_-	SLC-RABS-6N-_-	SLC-RABS-6P-_-
Nominal Size		1.2 meters (4’)		1.8 meters (6’)
External Dimensions (W x D x H)	Witout Base Stand	1340 x 820 x 1320 mm (52.8” x 32.3” x 51.9”)		1950 x 820 x 1320 mm (76.8” x 32.3” x 51.9”)
	With Base Stand (Min)	1522 x 820 x 1995 mm (59.9” x 32.3” x 78.5”)		2132 x 820 x 1995 mm (83.9” x 32.3” x 78.5”)
	With Base Stand (Max)	1522 x 820 x 2250 (59.9” x 32.3” x 88.6”)		2132 x 820 x 2250 mm (83.9” x 32.3” x 88.6”)
Main Chamber Work Zone (W x D x H)		840 x 610 x 670 mm (33.1” x 24.0” x 26.4”)		1450 x 610 x 670 mm (57.1” x 24.0” x 26.4”)
Pass Through (W x D x H)		355 x 610 x 670 mm (13.9” x 24.0” x 26.4”)		355 x 610 x 670 mm (13.9” x 24.0” x 26.4”)
Work Zone and Interchange Chamber Performance		ISO Class 5 (Class 1, Federal Standard 209E)
Inlet Filter Type		80% efficienct pre-filters
Downflow and Exhaust Filter Type		HEPA filter with integral metal guards and filter frame gaskets; fully compliant with EN 1822 (H14) and IEST-RP-CC001.3 requirements (each cabinet has individual downflow, exhaust filters and inlet filters).
Typical Filter Efficiency		>99.995% for particle size between 0.1 to 0.3 micron
Fluorescent Lamp Intensity		> 950 Lux (>88 foot candles)
RABS Construction	Main Body	1.2 mm (0.05”) 18 gauge electro-galvanized steel with white oven-baked epoxy-polyester antimicrobial powder-coated finish
	Work Tray	1.5 mm (0.06”) 16 gauge stainless steel, type 304, with 4B finish
	Side Walls	1.2 mm (0.05”) 18 gauge stainless steel, type 304, with 4B finish
Electrical	220-240V, AC, 50Hz, 1Ø	SLC-RABS-4N1-_	SLC-RABS-4P1-_	SLC-RABS-6N1-_	SLC-RABS-6P1-_
	Cabinet Full Load Amps (FLA)	2.1 A	2 A	2.5 A	2 A
	Optional Outlets FLA	5 A	5 A	5 A	5 A
	Cabinet Nominal Power	295 W	301 W	440 W	345 W
	Cabinet BTU	1007	1027	1501	1177
	110-120V, AC, 60Hz, 1Ø	SLC-RABS-4N2-_	SLC-RABS-4P2-_	SLC-RABS-6N2-_	SLC-RABS-6P2-_
	Cabinet Full Load Amps (FLA)	6 A	4 A	8.2 A	7 A
	Optional Outlets FLA	5 A	5 A	5 A	5 A
	Cabinet Nominal Power	410 W	264 W	600 W	456 W
	Cabinet BTU	1399	901	2047	1556
	220-240V, AC, 60Hz, 1Ø	SLC-RABS-4N3-_	SLC-RABS-4P3-_	SLC-RABS-6N3-_	SLC-RABS-6P3-_
	Cabinet Full Load Amps (FLA)	2.1 A	2 A	2.5 A	2 A
	Optional Outlets FLA	5 A	5 A	5 A	5 A
	Cabinet Nominal Power	295 W	301 W	440 W	345 W
	Cabinet BTU	1007	1027	1501	1177
Shipping Dimensions, Maximum (W x D x H)		1590 x 990 x 2210 mm (62.6” x 39.0” x 87.0”)		2150 x 950 x 2210 (84.6” x 37.4” x 87.0”)
Shipping Volume, Maximum*		3.48 m³ (122.9 cu.ft)		4.51 m³ (159.3 cu.ft)
* SLC-RABS only; excludes optional stand. ** Cabinet and GFCI outlet operate on a single power cord.

Accessories

Standard Accessories

Airlock pass-through
Vertical pass-through door
Horizontal tray for easy material transfer

Electrical Outlets and Utility Fittings

Electrical outlet, ground fault, North America
Electrical outlet, Euro/Worldwide

Support Stands

Fixed height, available 711 mm (28") or 864 mm (34") - With levelling feet, ± 38.1 mm (1.5") (SAL) - With casters (SPC)
Telescoping height stand for levelling feet (STL), nominal range 660 mm to 960 mm (26"to 37.8")
Telescoping height stand for casters (STC), nominal range 660 mm to 880 mm (26" to 34.6") - Adjustable in 25.4 mm (1") increments
Infinitely adjustable hydraulic stand with casters elevates to accommodate a sitting or a standing user’s work surface height (SHM)

Options

Electrical outlets
UV lamp
*Note: Clearly indicate in PO as UV lamp for SC-RABS is factory-installed.
Sharps disposal system
Alarm package
Exhaust carbon filter
Thimble exhaust collar
Perforated shelf to increase work zone space

Brochures & Sell Sheets

Esco Pharma Product Guide

Streamline Closed Restricted Access Barrier System (SLC-RABS) Catalogue

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